Sodium carbonate (Na2CO3) is the tenth most consumed inorganic compound all over the world. It is a safe compound and a vital component in several industrial cycles from the production of glass to dry powder detergents as well as lithium-particle batteries. It is likewise a significant ingredient in the pharmaceutical and food industries.
Sodium carbonate is the sodium salt of carbonic acid. It is commonly known as washing soda, sal soda, soda crystals and soda ash. It appears as a white powder, builds a firm alkaline aqueous and solution absorbs moisture from the air.
Sodium carbonate is ordinarily utilized as a water softener. It can be present in nature in the form of ashes from specific plants, and furthermore can be derived artificially in the lab from limestone and sodium chloride (salt) through the notable Solvay procedure.
Sodium carbonate is a significant raw material utilized in several applications such as its use in chemical reactions in the pharmaceutical sector as part of acid-base reactions. It might also be found in laundry-used water softeners, in toothpastes as an abrasive, some bubble bath solutions and in automatic dishwasher soaps.
Sodium carbonate play as an active pharma ingredient (API) or in the form of an excipient in pharmaceutical formulations to perform processes comprising PH adjustment. It is further extensively utilized as a buffering agent in effervescent tablets, dialysis solutions and antacids. The sodium carbonate utilized as an API is functional over issues related to indigestion and headache.
Furthermore, pharmaceutical-grade sodium carbonate is appropriate for the production of effervescent formulations utilized as delivery systems for OTC (over-the-counter) flu and cold remedies.
It is manufactured in facilities which are in compliancy with the ICH Q7A standard, cGMP (current Good Manufacturing Practices), as well as the U.S. Pharmacopeia 31st edition / National Formulary 26th edition standard. The pharmaceutical formulations for its production demand higher levels of purity in sodium carbonate.
Extensive Use as an Active Pharma Ingredient
The pharmaceutical grade sodium carbonate is the most finely and amid the purest form of the inorganic chemical. The uptake of pharmaceutical grade sodium carbonate is restricted to niche, specialty and definite high cost applications which necessitates higher levels of purity. Its uptake offers quality assertion for final pharmaceutical formulations. API is the key ingredient in a drug as well as is biologically active. It is primarily accountable for the accelerating the efficacy of the drug in curing diseases and associated symptoms. Several players in pharmaceutical industry utilizes sodium carbonate as APIs to improve their drug abilities. For example, Boots Company utilizes sodium carbonate in the form of an API in its effervescent powder which is employed to care for headaches and stomach issues.
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China has been one of the biggest manufacturers of sodium carbonate. The outbreak of COVID-19 disrupted the supplies chains of sodium carbonate in global markets leading to price hike of sodium carbonate. However, the production of sodium carbonate recovered after an preliminary lull as a result of the ease in lockdown.