An Unprecedented Rise of Unconventional Biological Matrices Using GCMS

To seek a perfect balance of justice and health, the new-generation forensic labs need to be accurate in terms of identifying and detecting a range of drugs of abuse and respective metabolites in case of biological matrices.

Urine and blood remain the traditional matrices of choice used for testing drugs of abuse, owing to their reliability and associated convenience. However, collection of these samples is an invasive process and the results are dependent on their dynamic molecular structure, which can alter at any moment resulting in inconsistency. Therefore, forensic analysts are aggressively looking for alternative sample types that enable convenient collection and provide precise information.

When considered in terms of advantages offered, alternative biological matrix are leaving traditional samples in the shade. Alternative biological matrix are minimally invasive in comparison to blood or urine, enabling the non-medical personnel to seamlessly gather samples amid a non-medical setting, resulting in substantial savings in terms of both time and money. One of such alternative biological matrix is hair, which enables tracing of molecules for a longer span of time. One of the major advantage associated with alternative biological matrix is abundance, which conveys that additional samples can be accumulated for sub sequential analysis.

The use of such biologically unconventional specimens is associated to a multitude of advantages, the most prominent ones being- minimal-or no risk of adulteration, non-invasive sampling, and ability to obtain desirable results with zero flaws.

To facilitate the development of quantitative assays for unconventional matrices, it is required to standardize protocol requirements for analysis of each specimen and establish appropriate certified reference materials. Gas chromatography systems, with competencies to address the aforementioned challenge, have made in-depth analysis of unconventional biological matrices easy and productive with impressive results.

The recent advances in gas chromatography tandem mass spectrometry (GCMS/MS) have enabled pin-point analysis of traditional and unconventional biological matrices with astounding speed and accuracy. Surging number of investments related to chromatography technologies by governments and prominent organizations and mushrooming number of collaborations between manufacturers as well as research laboratories are foreseen to be few of the key driving forces of gas chromatography systems market.