How Dimethylolpropionic Acid is used in Drug Release


Dimethylolpropionic acid is considered as a white crystalline solid that has a free flow and consists of two hydroxyl groups and one tertiary carboxylic group. Dimethylolpropionic acid acts as a diol as a result of lesser effects of the group of carboxylic acid. The group of free acid promotes resin water solubility, simplifies the initiation of a polar group to improve the receptiveness of synthetic fiber dye as well as coating adhesion. Furthermore, the group of free acid also helps in increasing the deposited films’ alkali solubility that finds various applications in dispensation of water soluble resins. The most important raw materials taken into account for producing dimethylolpropionic acid are propionaldehyde and formaldehyde. Dimethylolpropionic acid is used on a larger basis in (PUDs) Polyurethane Dispersions to advance the polyurethane polymer’s hydrophilic properties.

α-hydroxy Acids Used as Drug Release Modifiers

Efforts have been taken to prevail over the complications related to polymer degradation as well as dangerous effects inferred by its byproducts. Focus is on the preparation Pus along with the swelling controlled drug release instead of degradation based drug release. It was considered that, polymers comprising pendant basic or acidic groups either donate or accept a proton subject to the pH of the environmental media. By considering this, incorporation of pendent acidic groups has been done during synthesis of polyurethane’s by using α-hydroxy acids as chain extenders. Considering the nature of hydroxyl groups, the α-hydroxy-acids such as dimethylol propionic acid, glycolic acid and lactic acid were selected to incorporate in the structure of the polyurethanes. The three dissimilar α-hydroxy acids used as chain extenders were synthesized as well as labelled as DAPU, GAPU and LAPU, respectively.

In the case of DAPU, two hydroxyl groups are two hydroxyl groups, primary and secondary. Even after that, the crosslinking may perhaps be not as effective as GAPU, possibly due to steric interference provided by both the hydroxyl groups to each other. Amid DAPU and LAPU, even after being under the influence of steric interference, dimethylol propionic acid’s primary OH is more reactive than lactic acid’s secondary OH group. It also provides a better crosslinked structure of DAPU, compared to that of LAPU. The reason behind the reduced rate of drug release is the change of chain extender from LAPU to DAPU to GAPU. Therefore, the drug release was witnessed to be a direct purpose of swelling.

Additional Use of PUDs

PUDs are additionally used in applications such as wood finishing, automotive topcoats, glass fibre sizing, adhesives and many other applications. In the application of resin coating, DMPA is made use of in alkyd resins that are water soluble as well as polyester resins for minimal coupling solvent and improved hydrolytic stability. DMPA improves primary water spot resistance in the resins that are air dried. In the applications of powder coatings, DMPA is made use of in epoxy-polyester systems which helps in improving flexibility, flow properties, gloss as well as impact resistance of coatings. In electro deposition coatings, DMPA is used to improve the cure reaction as well as it allows the resin to be soluble in water.

More Analytical Insights

Compared to DMPA, penetration of DMBA in the PUDs industry has greatly increased at a faster rate. The demand for DMPA is increasing due to the growing PUDs industry in the developing economies as well as the rising dispersion of powder coatings in the industry of automobiles. Along with this, increasing investments in the polyesters resins market and increasing application of powder coatings in the automobile industry are factors that are driving the growth of global dimethylolpropionic acid market. The primary use of DMPA is in the manufacturing of resins and polyurethane dispersions. Applications are also found in the photographic chemicals as well as printing inks’ production. It has been found out that since past two years, the demand for these products have risen significantly across the globe. The aforementioned factors are anticipated to bolster the growth of global dimethylolpropionic acid market in the near future. To sum up, in order to advance the production and usage of dimethylolpropionic acid, Polyurethane Dispersions can be further improved and researched for better effects.

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By Nikhil Kaitwade

With over 8 years of experience in market research and consulting industry, Nikhil has worked on more than 250 research assignments pertaining to chemicals, materials and energy sector. He has worked directly with about 35 reputed companies as lead consultant for plant expansion, product positioning, capacity factor analysis, new market/segment exploration, export market opportunity evaluation and sourcing strategies.

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